Decreased SIRT1 expression in the cortex is closely associated with the accumulation of both A and Tau in AD patients (133), aberrant nuclearcytoplasmic localization of H3K4me3 has also been reported in early-stage AD (94), though its functional significance remains unclear (134)
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The integration of NPs with hydrogels further enhances therapeutic potential by enabling specific functionalization and sustained release, leveraging the hydrogel's versatile encapsulation capabilities
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"What effect does metformin have on vitamin B 12 levels?"
was supported by a SALK-grant from the government of Flanders and by an Odysseus-grant of the Research Foundation Flanders, Belgium (FWO)
